Fab-αHFc-CL-MMAE is a Fab fragment of anti-human IgG Fc specific antibody conjugated to monomethyl auristatin E (MMAE) with a cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. Monomethyl auristatin E (MMAE) is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The cleavable linker connecting MMAE to the antibody is stable in extracellular fluid, but can be cleaved by cathepsins upon entering cells. The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC.
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