Fab-αHFc-CL-DMSA is a Fab fragment of anti-human IgG Fc specific antibody conjugated to Duocarmycin SA (DMSA) with a cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. Duocarmycin SA (DMSA) is a cytotoxic small molecule which causes cell death by binding to the minor groove of DNA and alkylating the adenine. The cleavable linker connecting DMSA to the antibody is stable in extracellular fluid, but can be cleaved by cathepsins upon entering cells. The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC.
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