Fab-αHFc-NC-DM1 is a Fab fragment of anti-human IgG Fc specific antibody conjugated to maytansinoid DM1 with a non-cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. DM1 is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The non-cleavable linker connecting DM1 to the antibody is stable in extracellular fluid, but can be cleaved by unspecified mechanisms upon entering cells. The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC.
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